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1

From Drug Delivery Systems to Drug Release, Dissolution, IVIVC, BCS, BDDCS, Bioequivalence and Biowaivers

Vangelis Karalis, Eleni Magklara, Vinod P. Shah, Panos Macheras

Journal:

Pharmaceutical Research

Year:

2010

Language:

english

File:

PDF, 252 KB

english, 2010

2

Fractional kinetics in drug absorption and disposition processes

Aristides Dokoumetzidis, Panos Macheras

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2009

Language:

english

File:

PDF, 442 KB

english, 2009

3

Analysis of Dissolution Data Using Modified Versions of Noyes–Whitney Equation and the Weibull Function

Aristides Dokoumetzidis, Vasiliki Papadopoulou, Panos Macheras

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 400 KB

english, 2006

4

On the use of the Weibull function for the discernment of drug release mechanisms

Vasiliki Papadopoulou, Kosmas Kosmidis, Marilena Vlachou, Panos Macheras

Journal:

International Journal of Pharmaceutics

Year:

2006

Language:

english

File:

PDF, 211 KB

english, 2006

5

On the Heterogeneity of Drug Dissolution and Release

Panos Macheras, Aristides Dokoumetzidis

Journal:

Pharmaceutical Research

Year:

2000

Language:

english

File:

PDF, 75 KB

english, 2000

6

Quantitative Biopharmaceutics Classification System: The Central Role of Dose/Solubility Ratio

Eleni Rinaki, Georgia Valsami, Panos Macheras

Journal:

Pharmaceutical Research

Year:

2003

Language:

english

File:

PDF, 134 KB

english, 2003

7

Power law IVIVC: An application of fractional kinetics for drug release and absorption

John Kytariolos, Aristides Dokoumetzidis, Panos Macheras

Journal:

European Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 356 KB

english, 2010

8

On the ubiquitous presence of fractals and fractal concepts in pharmaceutical sciences: A review

Pippa, Natassa, Dokoumetzidis, Aristides, Demetzos, Costas, Macheras, Panos

Journal:

International Journal of Pharmaceutics

Year:

2013

Language:

english

File:

PDF, 1.54 MB

english, 2013

9

The Biopharmaceutics Classification System (BCS) and the Biopharmaceutics Drug Disposition Classification System (BDDCS): Beyond guidelines

Charalabidis, Aggelos, Sfouni, Maria, Bergström, Christel, Macheras, Panos.

Journal:

International Journal of Pharmaceutics

Year:

2019

Language:

english

File:

PDF, 944 KB

english, 2019

10

Non-linear regression analysis with errors in both variables: estimation of co-operative binding parameters

Georgia Valsami, Athanassios Iliadis, Panos Macheras

Journal:

Biopharmaceutics & Drug Disposition

Year:

2000

Language:

english

File:

PDF, 250 KB

english, 2000

11

A century of dissolution research: From Noyes and Whitney to the Biopharmaceutics Classification System

Aristides Dokoumetzidis, Panos Macheras

Journal:

International Journal of Pharmaceutics

Year:

2006

Language:

english

File:

PDF, 367 KB

english, 2006

12

Monte Carlo simulations for the study of drug release from matrices with high and low diffusivity areas

Kosmas Kosmidis, Panos Macheras

Journal:

International Journal of Pharmaceutics

Year:

2007

Language:

english

File:

PDF, 844 KB

english, 2007

13

Biopharmaceutics classification systems for new molecular entities (BCS-NMEs) and marketed drugs (BCS-MD): Theoretical basis and practical examples

Vasiliki Papadopoulou, Georgia Valsami, Aristides Dokoumetzidis, Panos Macheras

Journal:

International Journal of Pharmaceutics

Year:

2008

Language:

english

File:

PDF, 485 KB

english, 2008

14

Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability

Vangelis Karalis, Panos Macheras, Achiel Van Peer, Vinod P. Shah

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 138 KB

english, 2008

15

A Population Growth Model of Dissolution

Aristides Dokoumetzidis, Panos Macheras

Journal:

Pharmaceutical Research

Year:

1997

File:

PDF, 447 KB

1997

16

Drug Disposition Viewed in Terms of the Fractal Volume of Distribution

Vangelis Karalis, Panos Macheras

Journal:

Pharmaceutical Research

Year:

2002

Language:

english

File:

PDF, 217 KB

english, 2002

17

An Improved Intercept Method for the Assessment of Absorption Rate in Bioequivalence Studies

Panos Macheras, Mira Symillides, Christos Reppas

Journal:

Pharmaceutical Research

Year:

1996

File:

PDF, 532 KB

1996

18

A Heterogeneous Tube Model of Intestinal Drug Absorption Based on Probabilistic Concepts

Alkiviadis Kalampokis, Panos Argyrakis, Panos Macheras

Journal:

Pharmaceutical Research

Year:

1999

File:

PDF, 1019 KB

1999

19

Identification of Biowaivers Among Class II Drugs: Theoretical Justification and Practical Examples

Eleni Rinaki, Aristides Dokoumetzidis, Georgia Valsami, Panos Macheras

Journal:

Pharmaceutical Research

Year:

2004

Language:

english

File:

PDF, 206 KB

english, 2004

20

Current regulatory approaches of bioequivalence testing

Karalis, Vangelis, Macheras, Panos

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2012

Language:

english

File:

PDF, 437 KB

english, 2012

21

A non-binary biopharmaceutical classification of drugs: The ABΓ system

Macheras, Panos, Karalis, Vangelis

Journal:

International Journal of Pharmaceutics

Year:

2014

Language:

english

File:

PDF, 973 KB

english, 2014

22

Fractal kinetics in drug release from finite fractal matrices

Kosmidis, Kosmas, Argyrakis, Panos, Macheras, Panos

Journal:

The Journal of Chemical Physics

Year:

2003

Language:

english

File:

PDF, 350 KB

english, 2003

23

Pharmacokinetic Analysis of Inhaled Salmeterol in Asthma Patients: Evidence from Two Dry Powder Inhalers

Soulele, Konstantina, Macheras, Panos, Karalis, Vangelis

Journal:

Biopharmaceutics & Drug Disposition

Year:

2017

Language:

english

File:

PDF, 1.10 MB

english, 2017

24

On the dilemma of fractal or fractional kinetics in drug release studies: A comparison between Weibull and Mittag-Leffler functions

Kosmidis, Kosmas, Macheras, Panos

Journal:

International Journal of Pharmaceutics

Year:

2018

Language:

english

File:

PDF, 593 KB

english, 2018

25

General treatment of competitive binding as applied to the potentiometric ion probe technique: Application to the interaction of nonsteroidal anti-inflammatory drugs with bovine serum albumin

Alexandra Th. Angelakou, Evangelos E. Sideris, Georgia N. Valsami, Michael A. Koupparis, Panos E. Macheras

Journal:

Journal of Pharmaceutical Sciences

Year:

1994

Language:

english

File:

PDF, 610 KB

english, 1994

26

Construction of a diflunisal ion sensor and its use in automated flow-injection methods for assay, content uniformity, and dissolution studies of formulations

Petr Solich, Michael A. Koupparis, Panos E. Macheras

Journal:

Journal of Pharmaceutical Sciences

Year:

1995

Language:

english

File:

PDF, 749 KB

english, 1995

27

Monte Carlo simulations of drug release from matrices with periodic layers of high and low diffusivity

Kosmas Kosmidis, Panos Macheras

Journal:

International Journal of Pharmaceutics

Year:

2008

Language:

english

File:

PDF, 674 KB

english, 2008

28

Novel milk-based oral formulations: Proof of concept

Georgia Charkoftaki, John Kytariolos, Panos Macheras

Journal:

International Journal of Pharmaceutics

Year:

2010

Language:

english

File:

PDF, 867 KB

english, 2010

29

Analysis of Case II drug transport with radial and axial release from cylinders

Kosmas Kosmidis, Eleni Rinaki, Panos Argyrakis, Panos Macheras

Journal:

International Journal of Pharmaceutics

Year:

2003

Language:

english

File:

PDF, 102 KB

english, 2003

30

Modeling of supersaturated dissolution data

Georgia Valsami, Aristides Dokoumetzidis, Panos Macheras

Journal:

International Journal of Pharmaceutics

Year:

1999

Language:

english

File:

PDF, 92 KB

english, 1999

31

Nonlinear dynamics in Clinical Pharmacology: the paradigm of cortisol secretion and suppression

Aristides Dokoumetzidis, Athanassios Iliadis, Panos Macheras

Journal:

British Journal of Clinical Pharmacology

Year:

2002

Language:

english

File:

PDF, 216 KB

english, 2002

32

A commentary on fractionalization of multi-compartmental models

Aristides Dokoumetzidis, Richard Magin, Panos Macheras

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2010

Language:

english

File:

PDF, 220 KB

english, 2010

33

Fractional kinetics in multi-compartmental systems

Aristides Dokoumetzidis, Richard Magin, Panos Macheras

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2010

Language:

english

File:

PDF, 735 KB

english, 2010

34

Novel Scaled Bioequivalence Limits with Leveling-off Properties

John Kytariolos, Vangelis Karalis, Panos Macheras, Mira Symillides

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 236 KB

english, 2006

35

Physiologically-Based PK/PD Modelling of Therapeutic Macromolecules

Peter Thygesen, Panos Macheras, Achiel Van Peer

Journal:

Pharmaceutical Research

Year:

2009

Language:

english

File:

PDF, 224 KB

english, 2009

36

The Changing Face of the Rate Concept in Biopharmaceutical Sciences: From Classical to Fractal and Finally to Fractional

Aristides Dokoumetzidis, Panos Macheras

Journal:

Pharmaceutical Research

Year:

2011

Language:

english

File:

PDF, 154 KB

english, 2011

37

Ursodeoxycholic acid modulates cyclosporin A oral absorption in liver transplant recipients

François-Xavier Caroli-Bosc, Athanassios Iliadis, Laurent Salmon, Panos Macheras, Anne-Marie Montet, André Bourgeon, Rodolphe Garraffo, Jean-Pierre Delmont, Jean-Claude Montet

Journal:

Fundamental & Clinical Pharmacology

Year:

2000

Language:

english

File:

PDF, 690 KB

english, 2000

38

Modeling and Monte Carlo Simulations in Oral Drug Absorption

Aristides Dokoumetzidis, Kosmas Kosmidis, Panos Argyrakis, Panos Macheras

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2005

Language:

english

File:

PDF, 182 KB

english, 2005

39

Biopharmaceutical Classification Based on Solubility and Dissolution: A Reappraisal of Criteria for Hypothesis Models in the Light of the Experimental Observations

Georgia Charkoftaki, Aristides Dokoumetzidis, Georgia Valsami, Panos Macheras

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2010

Language:

english

File:

PDF, 134 KB

english, 2010

40

An alternative method for the estimation of the terminal slope when a few data points are available

Aristides Dokoumetzidis, Athanassios Iliadis, Panos Macheras

Journal:

Journal of Pharmaceutical Sciences

Year:

1999

Language:

english

File:

PDF, 62 KB

english, 1999

41

Fractal Volume of Drug Distribution: It Scales Proportionally to Body Mass

Vangelis Karalis, Laurent Claret, Athanassios Iliadis, Panos Macheras

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 204 KB

english, 2001

42

Nonlinear Dynamics and Chaos Theory: Concepts and Applications Relevant to Pharmacodynamics

Aristides Dokoumetzidis, Athanassios Iliadis, Panos Macheras

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 464 KB

english, 2001

43

Investigation of Absorption Kinetics by the Phase Plane Method

Aristides Dokoumetzidis, Panos Macheras

Journal:

Pharmaceutical Research

Year:

1998

File:

PDF, 568 KB

1998

44

Gastrointestinal Drug Absorption: Is It Time to Consider Heterogeneity as Well as Homogeneity?

Panos Macheras, Panos Argyrakis

Journal:

Pharmaceutical Research

Year:

1997

File:

PDF, 593 KB

1997

45

A Stochastic Model Describes the Heterogeneous Pharmacokinetics of Cyclosporin

Laurent Claret, Athanassios Iliadis, Panos Macheras

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2001

Language:

english

File:

PDF, 107 KB

english, 2001

46

A Fractal Approach to Heterogeneous Drug Distribution: Calcium Pharmacokinetics

Journal:

Pharmaceutical Research

Year:

1996

File:

PDF, 1.17 MB

1996

47

Carrier-Mediated Transport Can Obey Fractal Kinetics

Journal:

Pharmaceutical Research

Year:

1995

File:

PDF, 1.27 MB

1995

48

Evaluation of Different Metrics as Indirect Measures of Rate of Drug Absorption from Extended Release Dosage Forms at Steady-State

Cristos Reppas, Larry F. Lacey, Oliver N. Keene, Panos Macheras, Alan Bye

Journal:

Pharmaceutical Research

Year:

1995

File:

PDF, 775 KB

1995

49

Heterogeneous Tube Model for the Study of Small Intestinal Transit Flow

Alkiviadis Kalampokis, Panos Argyrakis, Panos Macheras

Journal:

Pharmaceutical Research

Year:

1999

File:

PDF, 881 KB

1999

50

The Cutoff Time Point of the Partial Area Method for Assessment of Rate of Absorption in Bioequivalence Studies

Panos Macheras, Mira Symillides, Christos Reppas

Journal:

Pharmaceutical Research

Year:

1994

File:

PDF, 531 KB

1994